A DEVELOPMENTAL TIMING SWITCH PROMOTES AXON OUTGROWTH INDEPENDENT OF KNOWN GUIDANCE RECEPTORS.

To form functional neuronal connections, axon outgrowth and guidance must be tightly regulated across space as well as time.While a number of genes and pathways have been shown to control spatial features of axon development, very little is known about the in vivo mechanisms that direct the timing of axon initiation and elongation.The Caenorhabditi

Objectives To examine valsartan, losartan and irbesartan usage and switching patterns in the USA, UK, copyright and Denmark before and after July 2018, when the first Angiotensin-Receptor-Blocker (ARB) (valsartan) was recalled.Design Retrospective cohort study.Setting USA, Canadian administrative healthcare data, Danish National Prescription Regist

PML/RARA is the oncoprotein driving acute promyelocytic leukemia (APL).It suppresses genes expression by recruitment of a number of transcriptional repressors, resulting in differentiation block and malignant transformation of hematopoietic cells.Here, we found that mice primary hematopoietic progenitor cells (HPCs), transduced by DNA-binding-defec

PML/RARA is the oncoprotein driving acute promyelocytic leukemia (APL).It suppresses genes expression by recruitment of a number of transcriptional repressors, resulting in differentiation block and malignant transformation of hematopoietic cells.Here, we found that mice primary hematopoietic progenitor cells (HPCs), transduced by DNA-binding-defec